Anti-migraine drug sumatriptan succinate, a 5-HT1B/1D-receptor agonist.
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منابع مشابه
DRUG PROFILE Update on sumatriptan: new progress in migraine treatment
10.2217/14750708.2.3.349 © 2 part of The introduction of the 5-HT1B/1D agonist sumatriptan in 1991 marked a significant advance in the management of migraine. Sumatriptan was the first migraine pharmacotherapy designed to selectively target the neurovascular origin of migraine pain. Sumatriptan was introduced in several formulations – injection, nasal spray, conventional tablet or suppository. ...
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Sumatriptan delivered in an electric patch form applied to the skin was approved by the Federal Drug Administration (FDA) in 2013 for the acute treatment of migraine. About 25 years ago, sumatriptan was the first drug in the medication class of triptans to be approved for the treatment of migraine. Sumatriptan already comes in a tablet, injectable form, nasal spray, and in at least 14 countries...
متن کاملActions of the 5-hydroxytryptamine 1 receptor agonist sumatriptan on interdigestive gastrointestinal motility in man.
BACKGROUND Pharmacological studies of the enteric nervous system have shown the presence of several subtypes of 5-hydroxytryptamine (5HT) receptor, which might be involved in control of the migrating motor complex. AIMS To study the effect of sumatriptan, an agonist of enteric neuronal 5HT1p receptors, on interdigestive motility in man. SUBJECTS AND METHODS In 12 healthy subjects, interdige...
متن کاملFreeze-dried k-carrageenan/chitosan polyelectrolyte complex-based insert: a novel intranasal delivery system for sumatriptan succinate
Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...
متن کاملFabrication and characterisation of lavender oil - plant phospholipid based Sumatriptan succinate hybrid solid lipid nanoparticles.
Background: Nanostructured lipid carriers (NLCs) of sumatriptan succinate (SS) were prepared by using lavender oil. In ancient days, lavender oil was used for the treatment of a migraine. The natural anti-migraine agent, lavender oil, combined with an anti-migraine drug such as SS in a nano-formulation, will be a practical alternative approach in migraine therapy. Objective: NLCs of sumatri...
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ژورنال
عنوان ژورنال: Folia Pharmacologica Japonica
سال: 2001
ISSN: 0015-5691,1347-8397
DOI: 10.1254/fpj.117.387